Guinea Pig Anti-Insulin Polyclonal Antibody INQUIRY

Cat.No: PRA-1009TL
Cat# PRA-1009TL
Product Name        Guinea Pig Anti-Insulin Polyclonal Antibody
Source Guinea Pig
Background Insulin is a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Immunohistochemical investigations have localized insulin in the beta cells of pancreatic islets of Langerhans. Insulin is also present in tumors of beta cell origin such as insulinoma. The presence of insulin in the cytoplasm of islet tumors is the most reliable indication of functional insulinomas.
Description Anti-Insulin is produced in the beta cells of the pancreas. The presence of insulin in the cytoplasm of islet tumors is the most reliable indication of functional insulinomas. Defective insulin storage occurs in insulinomas therefore, many sections of the tumor should be stained with both insulin and C peptide.
Species Reactivity Human
Clone  Polyclonal
Form Buffered aqueous solution
Application Immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
Storage 2-8°C
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